GSK3A polyclonal antibody
产品名称： GSK3A polyclonal antibody
英文名称： GSK3A polyclonal antibody
产品编号： PAB10015
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GSK3A.
- Immunogen:
- A synthetic peptide corresponding to amino acids 16-25 of human GSK3A.
- Host:
- Rabbit
- Reactivity:
- Chimpanzee, Human, Rat
- Specificity:
- This antibody will react with both the phosphorylated and non-phosphorylated form of the protein at the S21 residue. No cross reactivity is expected against GSK3B.
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:4000-1:16000)
Western Blot (1:500-1:3000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.
Gaster M, Brusgaard K, Handberg A, Hojlund K, Wojtaszewski JF, Beck-Nielsen H.Biochem Biophys Res Commun. 2004 Jul 9;319(4):1235-40.
- 2.
- Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?
Barry FA, Graham GJ, Fry MJ, Gibbins JM.FEBS Lett. 2003 Oct 9;553(1-2):173-8.
- 3.
- Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle.
Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, Henry RR.Diabetes. 2002 Jul;51(7):2190-8.
- Application Image
- Western Blot
- Immunofluorescence
- ELISA
- Entrez GeneID:
- 2931
- Protein Accession#:
- P49840;NP_063937
- Gene Name:
- GSK3A
- Gene Alias:
- DKFZp686D0638
- Gene Description:
- glycogen synthase kinase 3 alpha
- Omim ID:
- 606784
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM
- Other Designations:
- -
- Gene Pathway